Association of age with the level of response in the QuantiFERON-TB Gold In-Tube assay for children with active tuberculosis.

نویسندگان

  • Roumiana Markova
  • Rumiana Drenska
  • Petko Minchev
  • Yana Todorova
  • Massimo Ciccozzi
  • Massimo Amicosante
چکیده

QuantiFERON-TB data from 50 children with tuberculosis were analysed to evaluate age related effects. Significantly higher IFN-? responses to TB-specific antigens were associated with younger age, but no difference was found with Mitogen responses. Extrapolating IGRA responses to a Mitogen does not reflect those induced by an antigen-specific stimulus. QFT-IT responses to TB-specific antigens are not compromised with young age.

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منابع مشابه

QuantiFERON-TB Gold and Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Children

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Accuracy of the QuantiFERON-TB Gold in Tube for diagnosing tuberculosis in a young pediatric population previously vaccinated with Bacille Calmette-Guérin

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Accuracy of QuantiFERON-TB Gold Test for Tuberculosis Diagnosis in Children

OBJECTIVES To evaluate the accuracy of the QuantiFERON-TB Gold assay (QFT-IT) in children with suspected active or latent TB infection (LTBI). METHODS A retrospective study was conducted on 621 children (0-14 years old) evaluated for TB infection or disease. Following clinical assessment, children were tested with the QFT-IT assay. RESULTS Among the 140 active TB suspects, we identified 19 ...

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QuantiFERON®-TB Gold In-Tube Performance for Diagnosing Active Tuberculosis in Children and Adults in a High Burden Setting

AIM To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania. METHODS Sensitivity and specificity of QFT and TST for diagnosing active ...

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عنوان ژورنال:
  • The new microbiologica

دوره 34 1  شماره 

صفحات  -

تاریخ انتشار 2011